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KMID : 1035220090010010045
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Korean Journal of Neuromuscular Disorders
2009 Volume.1 No. 1 p.45 ~ p.50
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The Anatomy and Neuroimmmunology of Neuromuscular Junction
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Choi Young-Chul
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Abstract
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The Neuromuscular junction (NMJ) is the specialized structure between motor nerves and skeletal muscle, which consisted of presynaptic membrane, synaptic cleft and postsynaptic membrane. This complex structures converts nerve action potentials into muscle contraction. It is a target of a various neuroimmunologic disorders due to vulnerable to antibody-mediated attack. The main autoimmune disorders of NMJ are myasthenia gravis (MG)and Lambert-Eaton myasthenic syndrome (LEMS). The understanding of the immunological basis of MG and LEMS has improved in the recent years. This review provides the outline of the anatomy and physiology of the NMJ. It also focuses on recent advance of immunopathogenesis of NMJ disorder.
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KEYWORD
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Neuromuscular junction(NMJ), Myasthenia gravis, Lambert-Eaton myasthenic syndrome, Acetylcholine receptor, Muscle specific kinase(MuSK)
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